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Poly(ADP-ribose)polymerase-1(PARP-1)is a nuclear enzyme involved in the detection and repair of DNA damage.The inhibition of PARP-1 has several potential therapeutic applications for drug discovery.In an effort to discover novel PARP-1 inhibitors,our group disclosed a series of cyclic amine-substituted imidazo[4,5-c]pyridine derivatives as new PARP-1 inhibitors.