Deciphering the structural determinants of protein-protein interactions(PPIs)is essential to gain a deep understanding of many important biological functions in the living cells.
As a dangerous endpoint,respiratory toxicity can cause serious adverse health effects and even death.Meanwhile,it is a common and traditional issue in occupational and environmental protection.
G protein-coupled receptors(GPCRs)are still the largest target class in current drug discovery.Since 2007,with the great technology breakthroughs in GPCR crystallography,~150 GPCR complex structures h