基因治疗药物已成为当今生物技术药物研发的重点,而腺病毒是目前临床基因治疗较常选用的载体系统。它们在发挥治疗作用的同时,亦会引起机体出现毒性反应。从腺病毒载体及相应药物引发的毒性反应,固有免疫及获得性免疫系统活化等方面对它们的毒性及其机制进行总结。 Gene therapy drugs have become the focus of biotechnology drug research and development, and adenovirus is the most commonly used clinical gene therapy vector system. While they are playing a therapeutic role, they also cause toxic reactions in the body. From the adenovirus vector and the corresponding drug-induced toxicity, innate immunity and activation of the immune system and so on their toxicity and its mechanism are summarized.