Purpose: Melanoma-associated antigens-A (MAGE-A) family is a group of well-characterized cancer/testis antigens (CTA), because they are strictly tumor specific and are shared by many kinds of tumors.However, the expression pattern of MAGE-A10 and MAGE-A11 in breast cancer patients is still unclear.The purpose of our study is to investigate the expression pattern and prognostic significance of MAGE-A10 and MAGE-A11 in breast cancer patients.Methods: Formalin-fixed and paraffin-embedded tissues and the clinicopathological parameters from 75 primary breast cancer patients were collected.The expressions of MAGE-A10 and MAGE-A11 proteins were immunohistochemically detected, and the association of MAGE-A10 and MAGE-A11 expressions with the clinicopathological parameters and the survival of breast cancer patients were analyzed.Results: The expression rates of MAGE-A10 and MAGE-A11 in breast cancer specimens were 73.3% and 52.0%, respectively.MAGE-All expression was more frequent in estrogen-receptor (ER) positive breast carcinomas compared with ER negative breast carcinomas (P=0.004).MAGE-A11 expression was positively associated with HER-2 expression (P=0.003).Overall survival of patients with MAGE-A11 negative expression was significantly longer than those patients with positive MAGE-A11 expression (P=0.030), but no difference of overall survival was found between patients with MAGE-A10 negative and positive expression (P=0.881).Conclusions: MAGE-A10 and MAGE-A11 are tumor specific antigens, and MAGE-A11 expression probably is a potential poor prognostic factor for breast cancer patients.