【摘 要】
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As glucose-stimulated insulin secretion (GSIS) of pancreatic β cell is triggered and promoted by the metabolic messengers derived from mitochondria,mitochondri
【机 构】
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LaboratoryofProteomics,InstituteofBiophysics,ChineseAcademyofSciences,Beijing100101,China
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As glucose-stimulated insulin secretion (GSIS) of pancreatic β cell is triggered and promoted by the metabolic messengers derived from mitochondria,mitochondria take a central stage in the normal function of β cells.β cells in diabetics were chronically exposed to hyperglycemia stimulation,which has been reported to exert deleterious effects on β cell mitochondria.However,the mechanism of the toxic effects of hyperglycemia on β cell mitochondria was not clear.
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