【摘 要】
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Monoclonal antibodies (mAbs) represent the largest group of therapeutic proteins in development.To date, approximately 30 mAbs have been approved worldwide
【机 构】
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SeniorVicePresident&ScientificDirectorGenmabTheNetherlands
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Monoclonal antibodies (mAbs) represent the largest group of therapeutic proteins in development.To date, approximately 30 mAbs have been approved worldwide to treat various human diseases.Therapeutic mAbs exert their in vivo activity via the engagement of multiple mechanisms of action.Depending on the biology of the target molecule, the epitope recognized and the clinical application, therapeutic mAbs are selected or designed to act by four principal modes of actions: blockade, agonism, effector function recruitment, and immunoconjugate delivery.Novel insights into antibody biology and immunotherapy mechanisms set a strong foundation for the generation of next-generation antibody therapeutics with improved structure-function characteristics.This lecture will provide an overview of the field with a focus on exciting new developments.
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