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  5. Traceless pH sensitive coating of polyplexes prepared from well-defined polycations

Traceless pH sensitive coating of polyplexes prepared from well-defined polycations

来源 :The Third Symposium on Innovative Polymers for Controlled De | 被引量 : 0次 | 上传用户：zhang_jun
【摘 要】
：
Grene therapy is an attractive approach for the causal treatment of diseases associated with genetic malfunction.Critical requirements are stable nucleic acid packaging,cellular uptake and subsequent
【作 者】
：
Libor Kostka Linda Beckert Ana Krhac Levacic Tomas Etrych Ernst Wagner 
【机 构】
：
Centre for Biomacromolecular and Bioanalogous Systems,Department of Biomedicinal Polymers,Institute
【出 处】
：
The Third Symposium on Innovative Polymers for Controlled De
【发表日期】
：
2014年6期
【关键词】
：
gene delivery polyplexes proton-sponge hydrophilic shielding HPMA 
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　　Grene therapy is an attractive approach for the causal treatment of diseases associated with genetic malfunction.Critical requirements are stable nucleic acid packaging,cellular uptake and subsequent vesicular escape from endolysosomes to reach the cytoplasm.Delivery systems designed for in vivo systemic administration must overcome also the nonspecific interactions of polyplexes (PEC) with cells of the immune system and blood plasma proteins during their transport to target cells.These obstacles can be successfully suppressed by modifying the surface of PEC with covalently linked hydrophilic polymers [1].
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