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Objectives To elucidate effect of dual antiplatelet therapy on platelet response in acute myocardial infarction patients with chronic kidney disease.Methods From September 2011 to June 2012, a total of 195 acute myocardial infarction patients undergoing drug eluting stent implanting were enrolled, among them, 133 cases with normal renal function, and 62 cases with chronic kidney disease (CKD).