论文部分内容阅读
Strategy Toward The Pyridazinone Derivatives:The Synthetic Methodology of New Full-Color Tunable Flu
【机 构】
:
State Key Laboratory of Natural and Biomimetic Drugs,Department of Medicinal Chemistry,School of Pha
【出 处】
:
全国药物化学学术会议暨第四届中英药物化学学术会议
【发表日期】
:
2013年11期
其他文献
乳香酸类化合物11-氧代-β-乳香酸乙酸酯(Acetyl 11-keto-β-boswellic acid,AKBA)是一种乌苏烷型的五环三萜类化合物,主要来源于植物卡氏乳香(Boswellia carteri)的胶状树脂,含量约为3.7%[1],具有抗炎、抗肿瘤等多种生物活性.
Design,Synthesis,and Biological Evaluation of Azole-Oxadiazole Derivatives as Potent HIF-1 Inhibitor
会议
SL-01,dodecyl-3-((1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamoyl)pyrazine-2-carboxylate,is an oral gemcitabine derivative synthe
目的 阿尔茨海默病(Alzheimer’s disease,AD)是一种常见的中枢神经系统退行性疾病,临床表现为记忆力下降、社交能力出现障碍以及日常自理能力丧失等。
Definition of the binding mode of phosphoinositide 3-kinase α-selective inhibitor A-66S through mole
Activation of the phosphatidylinositol 3-kinase α(PI3Kα)is commonly observed in human cancer and is critical for tumour progression,which has made PI3Kα an attractive target for anticancer drug discov
Structure-based drug discovery and design for novel small molecular inhibitors of Sphingomyelin synt
Aim To discover novel small molecular inhibitors of sphingomyelin synthase(SMS)as a tool to study the biological function of sphingomyelin synthase and as a lead compound for new preventive and therap
Dendrimer-assisted formation of self-fluorescent nanogels for simultaneous drug delivery and intrace
会议
格尔德霉素(Geldanamycin,GA)属于苯醌安莎,是重要的抗肿瘤先导化合物.GA 通过竞争性结合Hsp90 N 末端ATP/ADP 结构域,特异性地抑制Hsp90 所必需的ATP 酶活性,从而改变Hsp90 构象,抑制其分子伴侣功能1-2.
Mammalian thioredoxin reductases(TrxRs),including cytosolic TrxR1,mitochondrial TrxR2,and testisspecific TrxR3,belongs to a homodimeric pyridine nucleotide disulfide oxidoreductases [1] and plays an i
Inteins are internal protein elements that self-excise from their host protein and catalyze ligation of the exteins with a peptide bond.
会议