Background, Motivation and Objective End stage heart failure is often treated with a left ventricular assist device (LVAD), when donor hearts are unavailable. Monitoring function of these patients is challenging due to the lack of suitable imaging techniques. Cardiac strain imaging (CSI) is a powerful technique which is able to quantify and localize cardiac defects, however, validation and reproducibility remain major issues. Simulations and phantoms are often not realistic, whereas in vivo measurements lack the ground truth and crucial information on governing parameters like pressures and flow, both related to the strains measured.