【摘 要】
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Cancer stem-like cells (CSC) have garnered significant attention as a therapeutic focus, based on evidence they may represent an etiologic root of treatment-resistant cells.Indeed, expression of the m
【机 构】
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State Key Laboratory of Oncology in South China;Cancer Center,Sun Yat-sen University;Collaborative I
【出 处】
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2014医学科学前沿暨第三届个体化治疗与抗肿瘤药物研究新趋向研讨会
论文部分内容阅读
Cancer stem-like cells (CSC) have garnered significant attention as a therapeutic focus, based on evidence they may represent an etiologic root of treatment-resistant cells.Indeed, expression of the multidrug resistance protein ABCG2 confers chemoresistance to CSC where it serves as a potential biomarker and therapeutic target.Here we show that afatinib, a small molecule inhibitor of the tyrosine kinases EGFR, HER-2 and HER-4, preferentially eliminated side population (SP) cells with CSC character, in both cell lines or patient-derived leukemia cells, by decreasing ABCG2 expression.
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