【摘 要】
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Paclitaxel(1) is a well known anticancer drug currently used in clinics especially for the treatment of ovarian,lung and breast cancer.Paclitaxel binds to t
【机 构】
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State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia M
【出 处】
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第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
Paclitaxel(1) is a well known anticancer drug currently used in clinics especially for the treatment of ovarian,lung and breast cancer.Paclitaxel binds to theβ-tubulin,promotes the polymerization of tubulin and inhibits the disassembly of microtubules to tubulin.Although paclitaxel showed potent antitumor activity,it suffered some undesired side effects as well as multi-drug resistance(MDR)..Here we report the synthesis of B-seco paclitaxel analogue,expecting to obtain new generation paclitaxel that can overcome drug resistance.
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