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Background Specific microRNAs (miRNAs) that are known to play an important role in a wide range of physiological and pathological processes in mammals are found in human breast milk, but the influencing factors and potential impact of these molecules on infant health are not fully understood.Objective To explore pre-and postnatal factors that can potentially influence let-7a, miRNA-30B and miRNA-378 in human milk, all of which are known to participate in adipogenesis.