【摘 要】
：
目的:探讨通塞脉片联合二甲双胍对实验性2型糖尿病大鼠血脂血糖的作用.方法:建立2型糖尿病大鼠模型80只,分为8组:模型对照组、二甲双胍组、通塞脉片12.44g/kg组(TSM Ⅰ)、6.22g/kg组(TSM Ⅱ)、3.11g/kg组(TSM Ⅲ)、二甲双胍联合通塞脉片12.44g/kg组(联合Ⅰ)、6.22g/kg组(联合Ⅱ)、3.11g/kg组(联合Ⅲ),同时另取正常小鼠10只作为正常对照组.
【出 处】
：
中华中医药学会第十次中药实验药理学术会议
论文部分内容阅读
目的:探讨通塞脉片联合二甲双胍对实验性2型糖尿病大鼠血脂血糖的作用.方法:建立2型糖尿病大鼠模型80只,分为8组:模型对照组、二甲双胍组、通塞脉片12.44g/kg组(TSM Ⅰ)、6.22g/kg组(TSM Ⅱ)、3.11g/kg组(TSM Ⅲ)、二甲双胍联合通塞脉片12.44g/kg组(联合Ⅰ)、6.22g/kg组(联合Ⅱ)、3.11g/kg组(联合Ⅲ),同时另取正常小鼠10只作为正常对照组.治疗组18d后观察其体重、血糖和血脂四项TC、TG、LDL-C、HDL-C.
其他文献
Myeloid-related protein MRP8, MRP14 and MRP8/14 complexes have been known as important endogenous damage-associated molecular pattern (DAMP) proteins.But the pathophysiological roles of MRP8, MRP14 an
Spinal cord injury results in damage to the vasculature and blood supply and in destruction of the brain-spinal cord fiber connectivity, leading to progressive tissue decay at the damage site and para
Background: Despite the indication that the beneficial effects of hypobaric hypoxia preconditioning (HHP) in heatstroke are related to induction of heat shock protein (HSP) 70 in vital organs, there h
Magnetic nanoparticle (MNP) has been demonstrated to be effective in target delivery of recombinant tissue-type plasminogen activator (rtPA) to increase local retention of the drug and induce thrombol
Aim: To study the effects of ganoderma lucidum polysaccharides peptide (GLPP) on cultured cardiomyocyte injury by hypoxia-reoxygenation (H/R) and to investigate its underlying mechanism.Methods: The c
Jia-Wey Shiau-Yau San (JWSYS), one of the traditional Chinese herbal formulas, is a famous herbal remedy used for the treatment of various menopause-related symptoms and stress-related neuropsychiatri
OBJECTIVES: Agmatine is known to be neuroprotective against brain apoptosis, astrogliosis, and edema in rat transient cerebral ischemia.The purpose of this study was to further assess the neuroprotect
目的:真武汤为《伤寒论》温阳利水经典方,具有温肾补脾,利水化湿之功效,临床用于心衰、慢性肾功能衰竭、慢性胃炎、神经内分泌系统疾病,本实验采取多种模型观察真武汤对小鼠抗应激作用、利尿作用及肾脏保护作用.方法:采用耐缺氧、耐高温、负重游泳实验,观察真武汤对对小鼠抗应激作用的影响;通过给予生理盐水负荷,滤纸称重记录法收集给药后4h内尿量变化,观察真武汤对小鼠的利尿作用;采用小鼠尾静脉注射阿霉素6.5mg
目的: 探索中药地黄对实验性甲状腺功能亢进症的治疗作用.方法: 96只昆明种小鼠每天每只皮下注射左旋甲状腺素钠250μg/kg造模,连续7-10天,从模型组和空白组中各随机抽取12只(雌雄各半),测定其耗氧量、心率和血清T3、T4含量,若模型组小鼠的这些指标均明显上升,可视为造模成功.后将造模成功的小鼠随机分为5组,每组12只,即分为甲亢模型组、地黄总苷低剂量组、地黄总苷中剂量组、地黄总苷高剂量组
目的:糖尿病肾病(Diabetic nephropathy,DN)是糖尿病(Diabetes Mellitus,DM)全身性微血管合并症之一,也是DN患者主要的死亡原因.本实验拟建立糖尿病肾病动物模型,观察芪药消渴胶囊对复合法致实验性糖尿病肾病(DN)大鼠的保护作用.实验方法: SD大鼠(雄性,体重200±20g,由第四军医大学实验动物中心提供,合格证号SCXK(军)2007-007.饲养环境:陕