Use of independent filtering in two-stage procedures for detecting genome-wide gene-environment inte

来源 :The Third IMS-China International Conference on Statistics a | 被引量 : 0次 | 上传用户：hysywlp2007

【摘要】

：

　　Several two-stage multiple testing procedures have been proposed to detect geneenvironment interaction in genome-wide association studies (GWAS), though the

【作者】

：

James Y.Dai

【机构】

：

FredHutchinsonCancerResearchCenter1100FairviewAveN,M2-C200,Seattle,Washington,USA,98109

【出处】

：

The Third IMS-China International Conference on Statistics a

【发表日期】

：

2011年7期

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　　Several two-stage multiple testing procedures have been proposed to detect geneenvironment interaction in genome-wide association studies (GWAS), though their theoretical properties and generalization have not been elaborated.In this article,we elucidate general condlitions that are required for the validity and the power of these procedures, and we dlisctss novel extensions to GWAS in randomized clinical trials (RCT).

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Use of independent filtering in two-stage procedures for detecting genome-wide gene-environment inte

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