【摘 要】
：
Cytochrome P450 (CYP) 3A4 is the principal drug-metabolizing enzyme in human liver and intestine, is also a target for various drug interactions of significant clinical concern.Drug-drug interactions
【机 构】
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Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Ch
【出 处】
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第十届全国药物和化学异物代谢学术会议暨第三届国际ISSX/CSSX联合学术会议
论文部分内容阅读
Cytochrome P450 (CYP) 3A4 is the principal drug-metabolizing enzyme in human liver and intestine, is also a target for various drug interactions of significant clinical concern.Drug-drug interactions (DDIs) caused by induction of CYP3A4 can result in decreased exposure to co-adiministered parent drugs and/or increased toxicity via increased formation of reactive metabolites.It is,therefore, important to understand a new compounds potemial for enzyme induction and to understand how to use the induction data generated in vitro to predict potential for DDIs in vivo.The aim of the present study was to develop a mechanistic physiologically based pharmacokinetic (PBPK)-enzyme turnover model characterizing CYP3A4-mediated induction and to predict the magnitude of metabolic DDIs between perpetrator and victim drugs.
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