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This study was designed to investigate effect of chronic intermittent hypobaric hypoxia (CIHH)on carotid sinus baroreflex (CSB) using Perfusion technique in isolated carotid sinus area in fructose-induced metabolic syndrome (Mets) rats.Sprague-Dawley rats were subject to treatment with fructose (10% fructose in drinking water for 6 weeks), CIHH (simulated 5000 m altitude, 6 hours per day for 6 weeks), and CIHH plus fructose.CSB was inhibited in fructose-induced Mets rats and enhanced in CIHH treated rats.The inhibition of CSB by fructose treatment was lightened in CIHH plus fructose treated rats.The facilitation of CSB in CIHH treated rats was partly abolished by Glibenclamide, a ATP sensitive potassium channel (KATP) blocker.