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Background: Locally advanced pancreatic cancer(LAPC)patients have a very poor prognosis and limited options for disease control.Local ablation technologies based on thermal damage have been used for these cases but are associated with major complications.IRE is a nonthermal ablation technology for structures near vital vascular and duct.The aim of this study was to evaluate the safety and efficacy of IRE as a part of multimodal treatment for LAPC in our center.