Transcriptome profiles provide a practical and inexpensive alternative to explore genomic data, particularly in organisms that have no accurate genome data published.Tibetan macaque (Macaca thibetana) is commonly considered as an endemic species to China and an important animal in biomedical researches nowadays.Limited knowledge of its genetic background has hindered research on this species.Peripheral blood is easily accessible and has been used as alternative tissue for monitoring individuals for various markers.Blood transcriptome profiling has earned its place in the molecular and cellular profiling approaches used to analyze the immune response in human and some other species.Rhesus macaque (M.mulatta) is the most widely studied species in the genus Macaca, and is used as a common biomedical research model.In this study, we reported the blood transcriptomes of Tibetan macaque from three individuals, and sequenced the blood transcriptomes of M.mulatta to be compared.Using Illumina HiSeq 2000 paired-end sequencing technology, 138 million sequencing reads of M.thibetana transcriptome were generated.The assembly yielded 327,871 transcripts with an average length of 990 bp and N50 length of 1,571 bp.According to the sequence similarity search against non-redundant (nr) protein database, 80,317 (24.5%) transcripts were annotated.