Theacrine, a purine alkaloid, act as a mitochondria SIRT3 activator to protect against MPP+/6-OHDA i

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Parkinsons disease (PD) is a kind of chronic neurodegenerative disease found in the elderly.It can be pathologically characterized by dopaminergic neuron degeneration and necrosis in substantia nigra, which in turn reducing striatal dopamine (DA) content.Protecting dopaminergic neurons has been considered to be an important strategy to prevent PD.
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