【摘 要】
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Background: Though known for their pleiotropic effects,bone anabolic statins have not been used for metabolic skeletal diseases due to the lack of tissue specificity to the skeleton.Recently, we devel
【机 构】
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University of Nebraska Medical Center, Omaha, NE, USA
【出 处】
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第七届国际骨质疏松及骨矿盐疾病学术会议
论文部分内容阅读
Background: Though known for their pleiotropic effects,bone anabolic statins have not been used for metabolic skeletal diseases due to the lack of tissue specificity to the skeleton.Recently, we developed a novel micelle-forming macromolecular prodrug of simvastatin (SIM).When administered systemically, this nano-sized drug delivery system would passively target to the fracture site and provide potent and locally sustained bone anabolic effects.This study was undertaken in an attempt to validate the osteotropism and the therapeutic efficacy of this prodrug in an osteotomized femur mouse model as well as the involved molecular/cellular mechanisms.
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