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Normalprostate contains the highest zinc levels in the body, and significant reduction of cellular zinc (60-70%) is the most consistent characteristic of prostate malignancy.The transformation of zinc accumulation may play a key role in the development and progression of prostate cancer, since high levels of cellular zinc is essential in normal prostate cells for the homeostasis of cell growth.Wehave previously shown that zinc treatment (15μM) induces apoptosis in prostate malignant PC-3 cells resulted from the zinc-induced mitochondrial release of cytochrome c,which initiates the caspase cascade leading to apoptosis.However, the mechanism by which zinc induces the release of cytochrome c and induces mitochondrial apoptogenesis has not been resolved.