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良好的子宫内膜容受性是胚胎着床成功的关键因素,近年来通过基因芯片技术展开了对子宫内膜容受性相关基因的高通量筛选研究。学者们通过对正常妇女正常月经周期子宫内膜基因表达差异的研究,初步总结出一些与子宫内膜容受性相关的基因,同时也发现子宫内膜异位症及不明原因不孕的妇女子宫内膜基因表达异于正常妇女,某些基因的异常表达可能影响子宫内膜容受性,从而造成植入失败引起不孕。而近期,促排卵周期子宫内膜基因的表达成为学者们研究的热点,人们正努力寻找能用于指导临床的子宫内膜容受性相关基因,这对了解植入失败原因、评估子宫内膜功能和预测妊娠结局将起到重要作用。
Good endometrial receptivity is a key factor for the success of embryo implantation. In recent years, high-throughput screening of endometrial receptivity-related genes has been carried out by gene chip technology. By studying the difference of endometrial gene expression in normal women’s normal menstrual cycle, scholars initially summarized some genes related to endometrial receptivity, and also found that endometriosis and unexplained infertility women’s uterus Endometrial gene expression is different from normal women, abnormal expression of some genes may affect endometrial receptivity, resulting in implanted failure resulting in infertility. Recently, the ovarian cycle of endometrial gene expression has become a hot topic of scholars, people are trying to find the clinical endometrial receptivity related genes, which understand the reasons for the failure of implantation, assessment of endometrial Function and prognosis of pregnancy outcome will play an important role.