【摘 要】
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Background:Chronic intermittent hypoxia is the primary pathophsiological feature of obstructive sleep apnea/hypopnea syndrome.The characteristics of CIH can be imitated by animal experiment models thu
【机 构】
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Department of Respiratory Medicine, Zhongshan Hospital affiliated to Fudan University,Shanghai, Chin
【出 处】
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中国医师协会中西医结合医师分会呼吸病专家委员会第二届学术研讨会
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Background:Chronic intermittent hypoxia is the primary pathophsiological feature of obstructive sleep apnea/hypopnea syndrome.The characteristics of CIH can be imitated by animal experiment models thus to study CIH related systemic organ injuries,including respiratory systems.Methods:Sixteen male SD rats were randomly divided into two groups:CIH group(n = 8)and control group(n = 8).The CIH group was exposed to intermittent hypoxia circumstance for 5 weeks(8 h/day)and control group was placed in the same animal chamber exposed to normal air circumstance.Between the two groups,the inflammatory factors of IL-6 and TNF-α within serum and BALF were measured by ELISA;the structure and ultrastructure of lungs were evaluated by HE staining and electronmicroscopy.The nuclear factor-κB(NF-κB)in lung tissue was detected by Western blot.
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