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Placental trophoblast cells differentiate into invasive trophoblasts or syncytiotrophoblasts.Abnormal trophoblast invasion results in pregnancy-associated disease and abortion.uPAR is a cell membranebound glycosylated protein, involved in physiological and pathological processes.However, uPAR expression in villi during threatened abortion and its role in trophoblast differentiation are unclear.We determined that, uPAR expression in the villi was reduced in threatened abortion patients than that in normal pregnancy.uPAR siRNA inhibited the potential for trophoblast migration and invasion in explant culture and HTR8/SVneo cells.It also enhanced forskolin-induced fusion of HTR8/SVneo cells.Overall,this study provides a possible reason for abortion, and might be a promising marker for the diagnosis and treatment for threatened abortion.