【摘 要】
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Nearly half of human cancers harbor TP53 mutations,which are predominantly through missense mutations that result in accumulation of mutant p53 proteins in cancer cells.More and more findings indicate
【机 构】
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Department of Laboratory Medicine,Affiliated Hospital of North Sichuan Medical College
【出 处】
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中华医学会第八次全国中青年检验医学学术会议
论文部分内容阅读
Nearly half of human cancers harbor TP53 mutations,which are predominantly through missense mutations that result in accumulation of mutant p53 proteins in cancer cells.More and more findings indicate that the mutant p53 proteins acquire gain-of-function abilities to promote carcinogenesis,metastasis,tumor recurrence and chemoresistance.TP53 mutations are the most frequent genetic alterations in breast cancer,observed in 30 ％of breast carcinomas,especially the triple negative breast cancer(TNBC),which most easily metastasizes and confers chemoresistance.
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