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Background: Primary intraosseous cavernous hemangioma is a rare bony tumor.To date,only 9 cases of multiple lesions and 2 cases with a dural tail sign have been reported.Case presentation: Here,we present a case of multiple cavernous hemangiomas of the skull with dural tail sign in a 24-year-old man.No abnormalities were observed in the right orbit by craniography,but frontal bone destruction was unintentionally discovered.Computed tomography and magnetic resonance imaging demonstrated multiple intraosseous lesions that destroyed the surrounding bone and intracranial extension.Total resection of the two lesions and cranioplasty were performed.Histological examination confirmed the lesions as a cavernous hemangioma.Conclusion: Cavemous hemangioma is a rare bony tumor that should be considered in the differential diagnosis of skull tumors.Resection of all lesions should be perfonned on patients with multiple cavernous hemangiomas,and these patients should have regular follow-up examinations.Based on this case,and our literature review,we found that outcomes are usually very good.