【摘 要】
:
Polyelectrolyte multilayers (PEMs) fabricated via dip coating layer-by-layer (LbL) assembly has gained a great interest in various fields.In the biomedical fields,these thin PEM coatings have been inv
【机 构】
:
Departments of Controlled Drug Delivery University of Twente,7500AE Enschede,The Netherlands
【出 处】
:
The Third Symposium on Innovative Polymers for Controlled De
论文部分内容阅读
Polyelectrolyte multilayers (PEMs) fabricated via dip coating layer-by-layer (LbL) assembly has gained a great interest in various fields.In the biomedical fields,these thin PEM coatings have been investigated for their possibility to modify cell-surface interaction and to add additional functionality for therapeutic effects [1].Multilayers have been fabricated on a wide range of polymer-based biomaterials,metal stents,sacrificial colloidal templates,to even the surface of cells to provide controlled and/or triggered release of (pro)drugs,growth factors,therapeutic proteins and DNA.
其他文献
The p53 gene has been widely investigated and considered to be an effective tumor suppressor in cancer gene therapy [1].To realize the clinical application ofp53-based gene therapy,developing safe and
Vaccination is an effective way to prevent and control pandemic H5N1 subtype influenza.H5N1split vaccine is of interest for its high safety,but its immunogenicity is relatively low.Thus,adjuvants are
Modern biotechnology has led to the development of a large invaluable family of potential therapeutic proteins.These proteins exhibit higher specificity and superior efficiency as compared to traditio
Nitric oxide (NO),known as an atmospheric pollutant and a potential health hazard,is recognized as an endothelium-derived relaxing factor (EDRF) and a broad-spectrum biological signaling molecule oper
Bone tissue engineering,aiming at developing bone substitutes for repair and regeneration of bone defects instead of using autologous bone grafts,is one of the fastest-growing branches in the field of
The use of transdermal drug delivery systems (TDDS) is an ideal route for drug administration,including various techniques such as chemical enhancers,iontophoresis,ultrasound,electroporation,microneed
Breast cancer has a high incidence among women [1] and almost all women with breast cancer should have surgery in the treatment,which can only remove the visible tumor tissues.The risk of recurrence i
The capability of smart response to the extracellular or intracellular microenviroments,such as overexpressed enzymes,and glutathione and pH differences,has become a necessary character of the antican
The disulfide-crosslinking approach has shown to elegantly resolve the extracellular stability and intracellular drug release dilemma of nanomedicines [1,2].In this study,novel reversibly crosslinked
The introduction of degradable oligopeptide sequences into the backbone of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-drug conjugates resulted in prolonged circulation time and increased tumor