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INTRODUCTION In mammals,Hypothalamus-Pituitary-Ovary (HPO) axis was one of the key endocrine and reproduction systems,which determined the attainment of secondary sexual characteristics and reproductive capacity.In this study, we profiled the genome wide DNA methylation of HPO tissues with Reduced Representation Bisulfite Sequencing (RRBS) (Yuan et al., 2016), and tried to descript and compare the distribution of differently methylated CpGs (DMCs) and regions (DMRs) in CpGs islands (CGIs) and gene locations among HPO tissues.