The value of microRNA-155 as a prognostic factor for survival in non-small cell lung cancer: A meta-

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  Background:Recent studies have shown that miR-155 play a positive role in the development of carcinoma.This meta-analysis aimed to identify the role of miR-155 in the survival of non-small cell lung cancer patients.Methodology : Eligible studies were identified through database searches.Relevant data were extracted from each eligible study to assess the correlation between miR-155 expression and survival in lung carcinoma patients.The hazard ratios (HRs) and 95% confidence intervals (CIs) of the patients' outcomes in relation to miR-155 were calculated.A total of 6 studies were included for this meta-analysis.For overall survival (OS), recurrence-free survival (RFS), disease-free survival (DFS), and cancer-specific survival (CSS), the combined HRs and 95% CIs were not statistically significant.Additionally, in Asian and America subgroups, greater expression levels of miR-155 were relate to poor prognoses for lung cancer (HR 1.71 95% CI:1.22-2.40, P=0.002, HR2.35 95% CI:1.42-3.89 P =0.001), while no significant relationship was present in a Europe subgroup (HR 0.75 95% CI:0.27-2.10, P =0.587).Conclusions :These results suggest that miR-155 expression is not significantly related to non -small cell lung cancer patients except in patients from Asian and America.
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