Objective: To investigate the effect of chemotherapy adjuvant radiotherapy (Gamma-knife) on the treatment of patients with re-treated advanced lung cancer.Methods: Eighty-six patients with stage Ⅲ/Ⅳ recurrent lung cancer were divided into three groups according to different treatment plans.Thirty-five cases treated with synchronous chemoradiotherapy belonged to the A group, 26 cases with sequential chemoradiotherapy belonged to the B group, and22 cases with continuous systematized chemotherapy alone belonged to the C group.The systemic three-dimensional orientation apparatus was used for radiotherapy.The total dose of 35 to 55 Gy was given in synchronous or sequential chemoradiotherapy.The chemotherapy regimen combined with radiotherapy was administered through a common dose as the first-line treatment against lung cancer.Second-or third-line chemotherapy was used in the C group only.