【摘 要】
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Aim To study the activity and mechanism of inhibition of myocardial hypertrophy of total flavonoids of Cydonia oblonga Mill.in spontaneously hypertensive rats.Methods Total flavonoids of COM (COMF) we
【机 构】
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Department of Pharmacology,Xinjiang Medical University,Urumqi 830011,China
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Aim To study the activity and mechanism of inhibition of myocardial hypertrophy of total flavonoids of Cydonia oblonga Mill.in spontaneously hypertensive rats.Methods Total flavonoids of COM (COMF) were separated and purified by the optimal process.SHR were divided into 6 groups: SHR control group (SHR), captopril group (SHR + CAP, 25 μg · g1), Eucommia ulmoides Oliver group (SHR + EUO, 30 μg · g1), low (SHR +COMFL, 40 μg · g1),middle (SHR + COMFM, 80 μg · g1) and high dose (SHR + COMFH, 160 μg ·g1) of COMF groups.WistarKyoto (WKY) rats (n =8) were given distilled water as control.The drugs were given by intragastric administration for 16 weeks.The histological and pathological examination of the heart were performed and organic damage were valued.The levels of Ang Ⅱ and ALD in blood and heart were evaluated.The mRNA and protein expression of ACE, ACE2 and AT1 was determined by RTPCR and Western blot to evaluate the effect of COMF on RAAS.Results Compared with SHR control group, HW, HW/BW, LVM and LVM/BW decreased in SHR + COMFM and SHR + COMFH groups; Cadiomyocyte hypertrophy was inhibited in COMF groups; The concentration of Ang Ⅱ and ALD in heart and blood decreased ; ACE and AT1 mRNA and protein expression in heart tissue decreased while ACE2 mRNA expression increased (P < 0.01 or P < 0.05), Conclusion Total flavonoids of Cydonia oblonga Mill.showed the effect of inhibition of myocardial hypertrophy in spontaneously hypertensive rats and the mechanism was related to.inhibit the activity of Reninangiotensinaldosterone system.
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