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Aim: Platelet-derived growth factor-BB (PDGF-BB) and its downstream effector,extracellular signal-regulated kinase1/2 (ERK1/2) of MAP kinase initiates a multitude of biological effects including proliferation and migration of vascular smooth muscle cells (VSMCs), critical events in the initiation and development of restenosis upon percutaneous transluminal coronary angioplasty (PTCA).