The epithelial-mesenchymal transition(EMT)is an important factor in lung cancer metastasis,and targeting EMT is a potential therapeutic strategy.Fucosyltransferase IV(FUT4)and its synthetic cancer sugar antigen Lewis Y(LeY)was abnormally elevated in many cancers.In this study,a traditional Chinese medicine ginsenoside Rg3 was used to investigate whether its inhibition to EMT and invasion of lung cancer is by the glycobiology mechanism.