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A hybrid pharmacophore approach was adopted to design and synthesize new series of pyridone-thiazole hybr ids.The structures of the compounds were established by IR,1H NMR,13C NMR,and HRMS.All the newly prepared hybrids were in vitro evaluated for their antiproliferative activity against three human cancer cell lines,namely Colon cancer(HCT-116),gastric carcinoma(MGC803) and hepatocellular cancer(Huh7).