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目的:观察和胃颗粒对实验性功能性消化不良胃肠运动障碍的调节作用。方法:以正常小鼠、FD模型大鼠、家兔离体肠管为实验对象,气滞胃痛颗粒和多潘立酮片为阳性对照药物,观察和胃颗粒低、中、高剂量对胃肠运动的影响。结果:和胃颗粒能促进正常小鼠的肠推进,对FD模型大鼠的胃排空和肠推进亦有明显的促进作用,对家兔离体肠管的自主收缩具有抑制作用,并对乙酰胆碱作用下的离体肠管痉挛有抑制作用。结论:和胃颗粒对功能性消化不良有确切的调节作用,其干预效应可能与整体性调节胃肠功能紊乱有关。
Objective: To observe the regulating effect of Hewei granule on experimental dysfunctional gastrointestinal motility dysfunction. Methods: The isolated intestine of normal mice, FD model rats and rabbits were used as experimental subjects. Qi-Wei-Weitong Granules and domperidone-tablets were used as positive control drugs to observe the effect of low and medium dose of stomach granules on gastrointestinal motility. Results: Hewei granule can promote the intestinal propulsion of normal mice, and also has a significant promoting effect on gastric emptying and intestinal propulsion in FD model rats, and has an inhibitory effect on spontaneous contractions of isolated intestinal intestines in rabbits, and its effect on acetylcholine Under the intestinal spasm in vitro inhibition. Conclusion: Hewei granule can regulate dysfunctional dysfunction and its intervention effect may be related to the overall regulation of gastrointestinal disorders.