应用ＳＤ大鼠观测铝在体内的代谢。设立铝１００ｍｇ／ｋｇ体重及４０ｍｇ／ｋｇ体重高、低两种剂量对大鼠进行灌胃，观察不同时间阶段铝在大鼠各组织的贮留、分布及４８小时尿、粪中排泄量。结果表明，两种剂量铝在组织中的贮留与分布不同。高剂量铝组２４小时、４８小时表观吸收率为１９．０７％～１９．４５％和３．５０％～７．７２％，表观贮留率为１６．８９％～２０．６７％和１．７０％～６．５４％；低剂量铝组２４小时、４８小时表观吸收率为２９．４０％～３６．５８％和３．７６％～１３．４８％，表观贮留率为２９．２７％～３６．４３％和３．６９％～１３．３５％，低剂量铝组在２４小时、４８小时的表观吸收率和贮留率均高于高剂量铝组的表观吸收率和贮留率。在高剂量铝组中，０．５小时肝脏、１小时肾脏、４８小时脑铝含量高于相应组织各时点铝含量；对于低剂量铝组，以肝脏铝含量最高，其次是脑和肾。而且从脑的结果可以看出，随着时间的延长，两种剂量组大鼠脑铝２４小时、４８小时含量高于同组内其他各时点，并且高剂量组脑铝浓度明显高于低剂量脑铝浓度（Ｐ＜０．０１），结果表明，不同剂量铝对大鼠脑有一定亲合力。高、低剂量铝组大鼠４８小时尿铝累积排出量占总摄入量的１．０? SD rats were used to observe the metabolism of aluminum in the body. Aluminum 100 mg / kg body weight and 40 mg / kg body weight were given to rats for gavage. The storage, distribution, excretion of aluminum in 48 hours and excrement of rats in different time periods were observed. The results showed that the two doses of aluminum in the organization of storage and distribution of different. The apparent absorption rate of high-dose aluminum group was 19.07% -19.45% and 3.50% -7.72% at 24 hours and 48 hours respectively, and the apparent retention rate was 16.89% -20.67% 1.70% ~ 6.54%. The apparent absorption rate of low-dose aluminum group was 29.40% -36.58% and 3.76% -13.48% after 24 hours and 48 hours respectively. The apparent storage rate was 29.27% ​​-36.43% and 3.69% -13.35% respectively. The apparent absorption rate and storage rate of low-dose aluminum group at 24 hours and 48 hours were higher than those of high-dose aluminum group Rate and retention rate. In the high-dose aluminum group, the content of brain aluminum in the liver at 0.5 hour, the kidney at 1 hour, the content of aluminum in the brain at 48 hours were higher than those at the corresponding time points. For the low-dose aluminum group, the liver had the highest aluminum content, followed by the brain and kidney. And from the results of the brain can be seen, with the extension of time, the brain of rats in both dose groups 24 hours, 48 ​​hours higher than other time points within the same group, and high-dose brain aluminum concentration was significantly higher than the low The dose of brain aluminum concentration (P <0.01), the results showed that different doses of aluminum on the rat brain has a certain affinity. High-dose and low-dose aluminum rats 48 hours cumulative urinary excretion of total intake of 1.0?