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Fas and its ligand (FasL) play important roles in the apoptosis and carcinogenesis.Polymorphisms in Fas (-670A>G,-1377G>A,) and FasL (-844C>T) implicated in cancer risk had been widely investigated.However, the conclusions were always inconclusive.Its urgent to carry out a meta-analysis to achieve a more precise estimation of the relationship between polymorphisms in Fas or FasL and cancer risk.Relevant studies were selected by PubMed and Web of Science, and 52 eligible literatures were involved in this meta-analysis.For Fas-670A>G polymorphism, no significant association was observed in the overall analysis.While for Fas-1377G>A polymorphism, results revealed AA genotype was associated with elevated cancer risk in the overall analysis.Further stratifications showed increased risks in breast, gastric and esophageal cancer, Asian population, population-based and hospital-based controls and studies carried by the method of PCR-RFLP.For FasL-844C>T, a significantly elevated cancer risk was associated with CC genotype in the overall analysis.Further stratifications showed increased risks in gastric, esophageal and ovarian cancer, Asian population, population-based and hospital-based controls and studies carried by the method of PCR-RFLP.This meta-analysis indicated the A allele ofFas-1377G>A and C allele of FasL-844C>T were risk factors for most of cancers.