【摘 要】
：
The CC chemokine ligand 18(CCL18)protein is a CC chemokine that takes an important part in normal and inflammatory conditions.Moreover,CCL18 has a higher expression in some tumors,while the serum CCL1
【机 构】
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Institute of Dermatology,Chinese Academy of Medical Sciences and Peking Union Medical College.Naniin
【出 处】
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江苏省遗传学会2016年学术研讨会
论文部分内容阅读
The CC chemokine ligand 18(CCL18)protein is a CC chemokine that takes an important part in normal and inflammatory conditions.Moreover,CCL18 has a higher expression in some tumors,while the serum CCL18 level can be a marker of tumor progression and prognosis.We previously showed that CCL18was high-regulated in cutaneous malignant melanoma(CMM)and the levels were correlated with tumor thickness.microRNAs(miRNAs)negatively modulate gene expression and have been implicated in oncogenesis.Our goal was to explore miRNAs which could target the CCL18 gene so as to mediate CMM development and improvement.By means of computative algorithms and RT-qPCR testing 14 CMM samples,we had found that the expression of miR-128 had a significantly negative relation with CCL18.
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