【摘 要】
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Objective: The purpose of this study was to determine the influence of weight loss on the survival of patients with NPC and to identify clinicpathological predictors for weight loss during the whole t
【机 构】
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Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong 510060
【出 处】
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第九届泛珠江区域放射肿瘤学学术大会暨肿瘤放射治疗多中心协作研讨会、重庆市医学会放射肿瘤治疗学专业委员会2014年会
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Objective: The purpose of this study was to determine the influence of weight loss on the survival of patients with NPC and to identify clinicpathological predictors for weight loss during the whole treatment (△W).Methods: 694 newly diagnosed patients with non-disseminated, biopsy-proven NPC were retrospectively reviewed.Body weight was recorded at baseline, at beginning of radiotherapy (RT), at end of RT, and at end of treatment.Weight loss during different time period was calculated.Results: High weight loss (HWL;△W ≥> 10%) was significantly associated with poor overall survival (OS;hazard ratio [HR]=2.110;95% CI, 1.403-3.171) and disease-specific survival (DSS;HR=1.854;95% CI, 1.215-2.830) in multivariate analysis.Weight loss during RT (△W-RT) and weight loss during adjuvant chemotherapy (△W-AC) were prognostic for OS (P=0.005;P<0.001).A prognostic WANT-model was developed based on △W, serum albumin, N classification, and T classificatiorn.Being female (P<0.001) and chemotherapy (P <0.001) were risk factors for HWL.Conclusion: Weight loss has significant prognostic value in patients with NPC.Increased attention should be paid to nutrition management during treatment in specific groups of patients who have increased susceptibility to HWL.
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