【摘 要】
：
Purpose To elevate the antibacterial effect of multivalent silver ion carried by zirconium phosphate (ZP-Ag) both in vitro and in experimental rat burn wound.Methods Minimal inhibition concentration (
【机 构】
：
Institute of Bum Research, Southwestern Hospital, Third Military Medical University Chongqing 400038
【出 处】
：
中华医学会烧伤外科学分会2009年学术年会
论文部分内容阅读
Purpose To elevate the antibacterial effect of multivalent silver ion carried by zirconium phosphate (ZP-Ag) both in vitro and in experimental rat burn wound.Methods Minimal inhibition concentration (MIC) and minimal bactericidal concentration (MBC) of ZP-Ag to three different strains of bacteria (Staphylococcus aureus,Pseudomonas aeruginosa and Escherichia coli) were determined in vitro compared with Sulfadiazine silver (SD-Ag) firstly.Then the dressings containing same mass of ZP-Ag or SD-Ag were prepared paralleling,and their anti-microorganism activities on infectious wounds in a rat bum model were assayed respectively.The responses of the wounds managed with the two kinds of prepared dressings were also checked.Results Both MIC and MBC of ZP-Ag to S.Aureus,P.Aeruginosa and Escherichia Coli were lower by two to four folds than those of SD-Ag.In vivo,we found that the dressing of ZP-Ag had much more effective antibacterial action to inhibit the growths of the above three strains under burnt scar than the dressing made from the same mass of SD-Ag.Moreover,the anti-microorganism effect was unchanged after the dressing with ZP-Ag was washed 20 times,while it was dramatically decreased after the dressing with SD-Ag washed 20 times.Covered by either regular or washed ZP-Ag dressing,the wounds showed integrity and no visible inflammatory reaction.Whereas various extents of inflammatory reactions on or around the wounds covered with regular SD-Ag dressing had been observed.Conclusion this study showed that the dressing with ZP-Ag had prominent and relative long-term antibacterial effect,which indicated that the ZP-Ag dressing could be a potential effective,low-cost management for bum wound.
其他文献
Lanthanum chloride,a rare earth compound,possesses antibacterial and cellular immunity-regulating properties.However,the underlying molecular mechanisms remain largely unknown.In this study,we examine
Lanthanide ions have been proved to have various biologic effects.Lanthanum with extremely active physical and chemical property was evidenced to possess antibacterial effects and regulating cellular
目的：介绍皮瓣移植围手术期的护理特点及对策方法：对35例皮瓣移植术患者的围术期进行护理与观察，总结与归纳其特点结果：通过加强术前做好心理护理及术区的检查与准备，术后密切观察患者全身状况和皮瓣移植术并发症各种情况，特别是血液循环障碍的护理与观察，及时发现，及时处理，提高皮瓣成活率。
目的：探讨老年烧伤患者心理反应，从而提出有效的护理措施。方法：对老烧伤患者恐惧、焦虑、疼痛、抑郁、绝望厌生等心理反应特点做好心理护理。结果：创造合适的住院环境，建立良好的护患关系，争取亲人的合作，密切观察患者身心变化，加强沟通交流与生活护理，减轻疼痛、帮助患者做好烧伤致残心理转变与适应的护理对策，不时解决患者的心理压力，保证各项治疗计划顺利进行。
护士在进行各项护理工作中，常会因为各种原因而导致患者不满、甚至差错及纠纷的发生。一起医疗纠纷或差错、事故的发生，不仅可给一个护士或一所医院带来负面影响，更主要的是可造成患者及家属的损失，而且可招致医院信誉度的下降，而患者群体安全感丧失的影响一时很难消除。因此，临床护理工作的安全问题，已成为衡量护理质量最敏感的指标。如何预防医疗纠纷、杜绝护理差错、事故的发生，已成为护理管理者的重要工作内容。现就我院
目的：观察溃疡膏加白糖在治疗烧伤耐甲氧西林金黄色葡萄球菌(MRSA)感染创面的临床效果,提高残余创面治愈率。方法：回顾性总结我科1996年1月～2008年10月期间收治的烧伤患者,创面分泌物细菌培养为MRSA感染者52例,创面处理在溃疡膏内加入白糖,创面用约1∶5000的高锰酸钾溶液清洗干净,直接涂抹溃疡膏后覆盖凡士林纱布,半暴露或者干纱布包扎,根据创面感染控制情况每日或者间隔1～-2天换药1次。
目的：本研究比较了两性霉素B脂质体与大扶康作为重度烧伤的经验性抗真菌治疗的安全性和有效性。方法：在一项开放、随机研究中,38例至少接受72小时抗细菌治疗的患者,接受两性霉素B脂质体或大扶康静脉给药,患者接受治疗时间最长为41天。主要安全性参数是因任何不良事件所致的永久停用研究药物。疗效参数指两个治疗组的有效性及成功率。结果：大扶康组因任何不良事件中止治疗的患者与对照组无明显差别。中止治疗的原因是血
目的：本实验研究移位细菌和内毒素的经淋巴途径和血液途径分布的动态过程,以及细菌内毒素进入体循环的不同途径之间的差别.方法：60只清洁级Wistar大鼠随机分为烫伤组(30只),假烫伤组(30只).CM-Dil标记大肠杆菌,胃饲大肠杆菌液,背部制作深Ⅱ度模型.于伤后2,24,72小时进行取材：血液、肠系膜淋巴结、肝脏、脾脏等.荧光显微镜下观察标记的细菌,计算细菌密度,鲎试剂显色基质法定量测定淋巴液内
目的：早期致炎因子IL-18、晚期致炎因子HMGB-1,抗炎因子IL-10作为指标对烧伤后肠系膜淋巴结、肠淋巴、肝脏和肝静脉的炎症反应情况进行了研究,以评估肠淋巴在烧伤感染中的状态.方法：40只大鼠随机分为烫伤组S(Scalds,30只),假烫伤组C(Control,10只),采集肠淋巴液、肝静脉血液、肠系膜淋巴结、肝脏、脾脏.ELISA法测量IL-18、10 Western Blotting检测
全身炎症反应综合征(SIRS)在严重烧伤患者相当常见,治疗困难.连续性血液净化在严重创伤、全身炎症反应综合征(SIRS)、脓毒症(sepsis)和多器官衰竭等病征的救治中取得了良好的疗效[1,2],被列为近20年来危重病救治的重要进展之一.但有关CBP对各种致病因子的清除以及对血中这些因子浓度的影响,文献报道结果不一.1996年以来,我科选择性对12例严重大面积烧伤患者进行CBP治疗,对治疗前后外