Urotensin Ⅱ protects cardiomyocytes from apoptosis induced by oxidative stress through cystathionine

来源 :中国病理生理学会心血管专业委员会第十五届学术大会暨国际心脏研究会中国分会第十二届学术大会 | 被引量 : 0次 | 上传用户:cxcqjf
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Plasma urotensin Ⅱ (UⅡ) has been observed to be raised in the patients with acute myocardial infarction, and a lower UⅡ response is associated with severer injury of myocardium, suggesting a possible cardioprotective role of this peptide.In the present study,we studied plasma UⅡ concentration of 30 patients admitted to the Cardiology Department with acute myocardial infartion.
其他文献
目的 探讨微泡超声造影在子宫肌瘤诊断与鉴别诊断中的应用价值.方法 采用造影剂SonoVue联合造影匹配成像技术对19例子宫肌瘤患者进行实时超声造影检查.观察病灶内造影剂灌注过程及造影后声像图特征,分析时间-信号强度曲线,指标包括显影时间、达峰时间、基础峰值强度及半廓清时间,并与常规二维超声及手术病理结果对照.结果 19例子宫肌瘤中单发5例,多发14例,其中肌壁间肌瘤19个,浆膜下肌瘤10个,黏膜下
目的 探讨低强度聚焦超声体外局部靶向爆破脂质微泡的能力;探讨低强度聚焦超声体内定位靶向爆破载阿霉素新型微泡并更精确地定位释放药物的能力。方法 采用机械振荡法制备普通脂质微泡,将脂质微泡稀释后放入自制的乳胶水囊中,分别用同等强度的普通诊断超声和低强度聚焦超声辐照10 s后,采用二维超声显影模式观察普通诊断超声和低强度聚焦超声靶向破坏微泡的范围;选取20只健康新西兰大白兔,将新型载阿霉素微泡经兔耳缘静
目的 构建靶向PHD2基因的shRNA真核表达载体,探讨应用超声靶向破碎微泡联合PEI介导PHD2-shRNA转染对H9C2心肌细胞PHD2基因的沉默效应,及其间接促进HIF-1α和下游促血管生成因子(VEGF、TGF-β3及bFGF)基因表达的可行性.方法 构建靶向PHD2基因的shRNA真核表达质粒及对照质粒(单纯EGFP质粒).体外常氧、缺氧培养H9C2心肌细胞,分为4组:①对照质粒常氧组;
AIM: Hypertrophy is one of the common pathological characteristics in diverse cardiovascular diseases, such as hypertension,heart failure and cardiovalvulitis.MicroRNAs play an important role in many
会议
AIM: Oxidative stress and intracellular Ca2+ overload are generally considered to be main factors responsible for ischemia/reperfusion (I/R) injury.However, the post-ischemic myocardial performance an
会议
AIM: Hypertensive heart disease is the major cause of cardiovascular morbidity and mortality.Recent study has shown that TGFβ/Smad3 signaling plays a critical role in cardiac remodeling during the pro
会议
AIM: Previous studies demonstrate that biological aging exerts a negative effect on the therapeutic effects of mesenchymal stem cell (MSC)-based therapy.Here, using a rat myocardial infarction (MI) mo
会议
AIM: L-type calcium channel participates in the regulation of a variety of physical and pathological process.In vasculature, it mainly mediates agonist-induced vascular smooth muscle contraction.
会议
AIM: Sepsis or septic shock is a severe complication after severe trauma or infection, and its morbidity and mortality were still high despite great development in medicine and techniques recent years
会议
AIM: Macrophage migration inhibitory factor (MIF) possesses proinflammatory function when secreted from the cells, it also exhibits antioxidant properties based on its intrinsic oxidoreductase activit
会议