目的 评价孕酮对6-OHDA所致SH-SY5Y细胞损伤的保护作用,并探讨其相关分子机制.方法 多巴胺能SH-SY5Y细胞以50,000/孔的密度种板,次日预孵育不同浓度的孕酮(0.1,1,10 μM)及孕激素受体拮抗剂米非司酮(7.5 μM)1 h,后加入神经毒剂6-OHDA (150 μM)以模拟帕金森病(Parkinsons Disease,PD)的神经损伤过程.
目的 分析花生四烯酸和谷胱甘肽代谢膜关联蛋白(membrane associated proteins in eicosanoid and glutathione metabolism,MAPEG)家族各成员的生物学特征,探讨该家族成员在现代药理毒理学研究中的潜在作用和意义.
Objectives Acute myocardial infarction can cause various arrhythmias.It is postulated that activation of autonomic nervous system induced arrhythmias.The developments of dynamic electrocardiogram prov
Objectives To study the relationship between high-sensitive cardiac troponin T (hs-cTnT) level and angiographic severity and extent of coronary stenosis in patients with chronic coronary artery diseas
Objectives Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates hepatic LDL receptors, playing a key role in cholesterol metabolism.Gain of function genetic mutations cause autosomal domina
Objectives To explore the effects of Cardiac Shock Wave Therapy (CSWT) on the Microvolt-T-wave alternans (MTWA) of CAD Patients.Methods A total of 87 patients with old myocardial infarction (OMI) were
Objectives The aim of the study is to 1.observe the changes of circulating visfatin levels in patients with coronary heart disease (CHD), 2.and investigate the relationship between visfatin levels and
Objectives To investigate the change of asymmetric NG, NG-dimethyl-L-arginine (ADMA) and elucidate the possible mechanism of endothelial dysfunction in patients with unstable angina.
Objectives The European System for Cardiac Operative Risk Evaluation (EuroSCORE) is a commonly used risk model worldwide for the predicting mortality after cardiac surgery and the Sino System for Coro
Objectives To explore the effects of Cardiac Shock Wave Therapy (CSWT) on the angiogenesis Related Cytokine of CAD Patients.Methods A total of 87 patients with old myocardial infarction (OMI) were enr