Background: Employing a radial approach in patiens undergoing PCI decreses mainly local bleeding and by this way also cost of the procedure.However, limiting data are available on cohort of ST-elevation myocardial infarction (STEMI) patiens undergoing primary PCI.Method: Between January-December 2009, 420 patients were treated for STEMI using primary PCI in our center.Among these, 310 patients (74%) were treated by primary PCI using radial approach.Mean age of this cohort was 62 years and 80% were males.The most often treated vessel was left anterior descending (LAD), followed by RCA (40%).The majority of patients had single vessel disease (89%).TIMI flow 0/1 was found in 66%.97% ofpatiens were in KILLIP class Ⅰ/Ⅱ.GP Ⅱb/Ⅲa inhibitors were used in 18% ofpatiens and thromboaspiration in 36%, respectively.Intra-aortic balloon pumping (IABK) was used in 1%.The majority of patients received 1 stent.Of note, 5% (16) of patiens was treated only by thrombo-aspiration.Mean door-to-balloon time (D2B) and mean floroscopy time was 22 and 10 minutes, respectively.There was not any case of conversion to femoral approach and no case of local bleeding complication.The 30-day mortality was 1%.Conclusion: Radial approach in STEMI patients is safe and does not represent either a delay in D2B time or prolongation of fluoroscopy time in selected patients group.Furthermoe, it also reduces local bleeding complication.