B7-H1通过IL-21诱导Ⅰ型调节性T细胞介导免疫抑制

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：df_871

【摘要】

：

研究背景:调节性T细胞(Treg)在建立和维持外周免疫耐受中具有十分重要的作用.Ⅰ型调节性T细胞(Tr1)是初始CD4+T细胞在外周组织中存在IL-10的条件下,遇到外来或组织特异性自身抗原时被诱导产生的,不表达Foxp3,主要通过其进一步分泌抑制性细胞因子IL-10发挥免疫调节功能.我们以往的研究证实,无论是APC表面的膜型B7-H1分子,还是可溶性B7H1-Ig融合蛋白,在体外均能作为共刺激分

【作者】

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邵晓轶路丽明周芸汪晓莺周光炎

【机构】

：

南通大学医学院免疫学系;上海交通大学医学院上海市免疫学研究所上海交通大学医学院上海市免疫学研究所

【出处】

：

中国免疫学会第九届全国免疫学学术大会

【发表日期】

：

2014年8期

【关键词】

：

B7-H1 调节性T细胞 IL-21 免疫抑制

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B7-H1通过IL-21诱导Ⅰ型调节性T细胞介导免疫抑制

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