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Aim: Oligomer procyanidins (F2, degree of polymerization 2-15), a natural fraction isolated from grape seeds, was demonstrated to inhibit the multiple kinds of tumor cells growth and migration in our previous study.Grape seed extract (GSE) was reported to inhibit HIF-1 pathway and its target.In this study, the effect of F2 on HIF-1 activity and the underlying mechanism were investigated.