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  5. Stabilizing approach for glycyrrhetinic acid nanosuspensions

Stabilizing approach for glycyrrhetinic acid nanosuspensions

来源 :2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会 | 被引量 : 0次 | 上传用户：nesecueity
【摘 要】
：
Objective: To investigate the influence of different stabilizers on the particle size of glycyrrhetinic acid (GA) nanosuspension during freeze-drying and/or storage, and to obtain the optimal formulat
【作 者】
：
LEI Ya-ya SUI Hong WANG Wen-ping 
【机 构】
：
School of Pharmacy, Ningxia Medical University Sc
【出 处】
：
2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会
【发表日期】
：
2015年9期
【关键词】
：
glycyrrhetinic acid nanosuspension stabilizer 
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　　Objective: To investigate the influence of different stabilizers on the particle size of glycyrrhetinic acid (GA) nanosuspension during freeze-drying and/or storage, and to obtain the optimal formulation.Methods: GA nanosuspension was prepared by anti-solvent precipitation and high-speed shear method.Different stabilizers were systematically screened based on the particle size distribution, redispersibility index and sedimentation ratio of the obtained nanosuspensions.
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