Cisplatin,one of the most common anticancer drugs,binds to DNA and forms platinum-DNA crosslinks,leading to partial unwinding and distortion in the DNA duplex which blocks DNA replication and ultimate
It is well established that the C.elegans insulin/IGF-1 receptor tyrosine kinase DAF-2 acts though a highly conserved kinase cascade consisting of AGE-1(PI 3-kinase),PDK-1,AKT-1,and AKT-2 to inhibit t
Native 1DE has been widely used in biochemical studies concerning protein complex formation,subunit structures and enzymatic activities for it provides high-resolution separation of proteins without d