Knockdown of versican V1induces a severe inflammation in LPS-induced ALI via the TLR2-NF-κB pathway

来源 :2016中华医学会呼吸病学年会暨第十七次全国呼吸病学学术会议 | 被引量 : 0次 | 上传用户:datangkang123
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  目的 The versican family is important in the modulation of inflammation,however,the role of versican V1(V1)inlipopolysaccharide(LPS)?induced acute lung injury(ALI)and the underlying mechanisms remain to be elucidated.方法 To investigate this,the present study performed experiments in male C57BL/6J mice,which were randomly divided into anormal control group(control; n=6),an LPS?stimulated ALI group(LPS; n=6),a scramble small interfering(si)RNA group(scramble; n=6),a V1?siRNA group(V1?siRNA; n=6),a scramble siRNA and LPS?stimulated group(scramble+LPS; n=6)and a V1?siRNA and LPS?stimulated group(V1?siRNA+LPS; n=6).
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