【摘 要】
：
With advances in biomaterials,various novel artificial gels with capability to respond to stimuli (e.g.,temperature,light,force,pH) have emerged with great potential applications in drug delivery [1].
【机 构】
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Bioinspired Engineering and Biomechanics Center(BEBC),Xi'an Jiaotong University,28 Xianning West Rd
【出 处】
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The Third Symposium on Innovative Polymers for Controlled De
论文部分内容阅读
With advances in biomaterials,various novel artificial gels with capability to respond to stimuli (e.g.,temperature,light,force,pH) have emerged with great potential applications in drug delivery [1].Among them,chemomechanical gels,exhibiting bioinspired energy transformation between volume deformation and chemical reaction,are expected to be a better vehicle for the drug delivery system due to their intelligent,controllable and especially biomimetic behavior.In this study,we proposed a general model coupling the large deformation,chemical reaction and mass diffusion to describe the complicated behaviors of chemomechanical gels [2].Furthermore,the simulation of the drug release from these gels under an external cyclic force demonstrated that the amplitude and period of the external force significantly affect the released drug quantity of each squeeze.These investigations are supposed to further understand and develop the application of chemomechanical gels in drug delivery.
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